Frameshift Insights
Methodological essays on epidemiology, biostatistics and study design.
A new Danish nationwide register study followed 1.5 million children and found no association between prenatal acetaminophen exposure and autism, even in a sibling-matched analysis. A look at what the study shows, what the registers made possible, and why the evidence has only converged further.
The Guardian reported that CRC is now the #1 cancer killer in Americans under 50. We pooled 44 years of NORDCAN data across five countries. The trend is real, but the ranking is not: CRC is #3 in the Nordics for both sexes, and the rise is hitting young men hardest.
A 2013 Danish register study found that skin cancer patients had half the all-cause mortality of the general population. Swap the diagnosis for a lottery prize and the same design manufactures the same survival advantage, because the exposure is defined by having lived long enough to receive it.
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